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ORIGINAL ARTICLE
Year : 2013  |  Volume : 54  |  Issue : 6  |  Page : 411-414

Retarded hippocampal development following prenatal exposure to ethanolic leaves extract of Datura metel in wistar rats


1 Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
2 Addiction and Neurotoxicology Unit, Anatomy Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria

Correspondence Address:
Azeez Olakunle Ishola
P.O. Box 12962, Dugbe, Ibadan
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0300-1652.126299

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Background: Datura metel contains atropine alkaloids and has been used to treat complication like asthma and, bronchitis, because of its anticholinergic properties. Aim: This study aimed to determine the prenatal effects of ethanolic extract of D. metel leaves exposure on the development of hippocampus. Materials and Methods: Twenty rats (12 females and 8 males) were purchased. The females were grouped into four groups (A_D). Group A were given 500 mg/kg body weight of the extract on the first day of fertilization to the end of gestation period, Group B were given 500 mg/kg body weight on the 8 th day of fertilization to the end of gestation period, Group C were given 500 mg/kg body weight on 15 th day of fertilization to the end of gestation period and Group D were given normal saline throughout the gestation period. Results: Rats in Group A showed no implantation, rats in Group B had abortion on the 7 th day after administration, and rats in Group C gave birth with their litters showing retarded hippocampus development and neural degeneration and rats in Group D (control) showed normal development. Conclusion: Ethanolic extract of D. metel leaf is teratogenic in the late stage of pregnancy, is abortificient and can serve as a contraceptive.


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