ORIGINAL ARTICLE |
|
Year : 2013 | Volume
: 54
| Issue : 6 | Page : 411-414 |
|
Retarded hippocampal development following prenatal exposure to ethanolic leaves extract of Datura metel in wistar rats
Azeez Olakunle Ishola1, Philip Adeyemi Adeniyi2
1 Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Nigeria 2 Addiction and Neurotoxicology Unit, Anatomy Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
Correspondence Address:
Azeez Olakunle Ishola P.O. Box 12962, Dugbe, Ibadan Nigeria
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/0300-1652.126299
|
|
Background: Datura metel contains atropine alkaloids and has been used to treat complication like asthma and, bronchitis, because of its anticholinergic properties. Aim: This study aimed to determine the prenatal effects of ethanolic extract of D. metel leaves exposure on the development of hippocampus. Materials and Methods: Twenty rats (12 females and 8 males) were purchased. The females were grouped into four groups (A_D). Group A were given 500 mg/kg body weight of the extract on the first day of fertilization to the end of gestation period, Group B were given 500 mg/kg body weight on the 8 th day of fertilization to the end of gestation period, Group C were given 500 mg/kg body weight on 15 th day of fertilization to the end of gestation period and Group D were given normal saline throughout the gestation period. Results: Rats in Group A showed no implantation, rats in Group B had abortion on the 7 th day after administration, and rats in Group C gave birth with their litters showing retarded hippocampus development and neural degeneration and rats in Group D (control) showed normal development. Conclusion: Ethanolic extract of D. metel leaf is teratogenic in the late stage of pregnancy, is abortificient and can serve as a contraceptive. |
|
|
|
[FULL TEXT] [PDF]* |
|
|
|