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INNOVATION
Year : 2014  |  Volume : 55  |  Issue : 1  |  Page : 87-90

Successful pregnancy outcome after in vitro fertilisation following Pre-implantation Genetic Diagnosis/Polymerase Chain Reaction screening for single gene disorder (sickle cell anaemia) before embryo transfer: The clinical experience of an in vitro fertilisation clinic in Nigeria


1 Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria
2 Medical Assisted Reproductive Technology Centre, Ikeja, Lagos, Nigeria; University of Illinois, Chicago, Illinois, USA

Correspondence Address:
Chizara Okeke
Medical Assisted Reproductive Technology Centre, Ikeja, Lagos
Nigeria
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Source of Support: The study was supported by grants from OladapoAshiru Reproductive Health Solutions (OARS) foundation,, Conflict of Interest: None


DOI: 10.4103/0300-1652.128181

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A couple, both carriers of the sickle cell anaemia trait (Genotype HbAS) with an offspring already affected with the genetic disease underwent a Pre-implantation Genetic Diagnosis/Polymerase Chain Reaction screening of biopsied blastomeres. DNA analysis of single blastomeres was carried out to find out indicated a viable intra-uterine pregnancy with embryos which carried the sickle cell mutation, which resulted in a livebirth (HbAS). PGD/PCR in combination with IVF appears to be the most suitable treatment plan for patients who are at a higher risk of reproducing offspring affected with inheritable genetic diseases.


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