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Year : 2015  |  Volume : 56  |  Issue : 1  |  Page : 74-76

Coexistence of JAK2 and BCR-ABL mutation in patient with myeloproliferative neoplasm

Department of Haematology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

Correspondence Address:
Abdulaziz Hassan
Department of Haematology, Ahmadu Bello University Teaching Hospital, PMB 06 Shika, Zaria 810001, Kaduna State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0300-1652.149177

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The World Health Organisation (WHO) classifies myeloproliferative neoplasm (MPN) into BCR-ABL positive chronic myeloid leukaemia (CML Ph + ) and Ph MPN. The JAK2 V617F mutation is specific for Ph MPN and occurs in approximately 50% of primary myelofibrosis. Earlier reports suggest that the occurrence of JAK2 and BCR-ABL mutations are mutually exclusive. However, recent reports have documented the coexistence of BCR-ABL and JAK2 mutation in the same patient mostly following treatment with tyrosine kinase inhibitors (TKIs). We thus report a 60-year-old male with atypical clinical and laboratory features of MPN and the presence of both BCR-ABL and JAK2 Mutations.

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