|Year : 2015 | Volume
| Issue : 2 | Page : 126-131
Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011
Henry Okuchukwu Ebili1, Abideen Olayiwola Oluwasola2, Effiong EU Akang2, John Olufemi Ogunbiyi2
1 Department of Morbid Anatomy and Histopathology, Olabisi Onabanjo University Teaching Hospital, Olabisi Onabanjo University, Sagamu, Nigeria
2 Department of Pathology, University College Hospital, University of Ibadan, Ibadan, Nigeria
|Date of Web Publication||17-Mar-2015|
Henry Okuchukwu Ebili
Department of Morbid Anatomy and Histopathology, Olabisi Onabanjo University Teaching Hospital, Olabisi Onabanjo University, Sagamu
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Aim: The most recent study on the clinicopathological features of gastric carcinoma from the University College Hospital (UCH), Ibadan, was done in 2000. The aim of this study is to update the knowledge on the clinicopathological features of gastric carcinoma diagnosed in the Pathology Department of the UCH Ibadan between 2000 and 2011. Materials and Methods: This was a 12-year retrospective review of clinical and demographic data and the histopathological features of gastric cancers diagnosed at the Pathology Department of the UCH. The chi square test, Fisher's exact test, and the t-independent test were used as applicable in the statistical analyses. Results: A total of 117 cases of gastric carcinoma were histologically diagnosed at the Pathology Department of UCH, Ibadan in this period giving a relative ratio frequency of 1.38% for all cancers. It represented 18.4% of all gastrointestinal tract malignancies diagnosed in the same period. There was a male preponderance with male:female ratio of 1.72:1; the middle-aged and elderly made up about 76.1% of cases. The disease was clinically and histologically advanced in 92.8% of cases. Gastric tumours were predominantly antral/ pyloric in 80% of cases and exophytic in 62.3% of cases. The intestinal histotype constituted 47.0% cases although a rise in the diffuse histological type was observed. Conclusion: There is a decline in the relative ratio frequency of gastric carcinoma in Ibadan; and a fall in the rate of the intestinal type of gastric carcinoma relative to the diffuse type when compared to previous studies from our centre.
Keywords: Clinicopathological features, gastric carcinoma, Ibadan, Nigeria
|How to cite this article:|
Ebili HO, Oluwasola AO, Akang EE, Ogunbiyi JO. Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011. Niger Med J 2015;56:126-31
|How to cite this URL:|
Ebili HO, Oluwasola AO, Akang EE, Ogunbiyi JO. Clinicopathological features of gastric carcinoma in Ibadan, Nigeria, 2000-2011. Niger Med J [serial online] 2015 [cited 2020 Feb 27];56:126-31. Available from: http://www.nigeriamedj.com/text.asp?2015/56/2/126/150700
| Introduction|| |
Gastric cancer is the fifth most common cancer in the world with about 952, 000 cases reported worldwide in 2012; and the third leading cause of cancer mortality.  There is a wide geographical variation being highest in the Far East (Japan and China) and lowest in Africa. ,,,, The age-standardised incidence range from 3.3 in West African men to 35.4 in East Asian men; and from 2.6 in West African women to 13.8 in East Asian women. 
In Africa gastric carcinoma has a relatively higher incidence in Nigeria and South Africa than in francophone West Africa, Kenya and Egypt.  In Nigeria the prevalence rate is reported to be between 1.64% and 4.1% being highest in the South-West region and lowest in the North-East. ,,
The relative ratio frequency of gastric carcinoma in the University College Hospital (UCH) Ibadan has been declining over the past decades, from 3.6% in the 1980s to 2.73% in the 1990s as found by Ogunbiyi.  The most recent work on gastric carcinoma in the UCH, Ibadan by Oluwasola and Ogunbiyi in 2000 described the clinicopathological features of gastric carcinoma cases seen at the Pathology Department between 1980 and 1997.  The aim of this study is to update the present data on the clinicopathological features of gastric carcinoma in UCH, Ibadan.
This study was approved by the University of Ibadan/UCH Ethics Committee.
| Materials and methods|| |
All the gastric carcinoma cases diagnosed at the Pathology Department, UCH, Ibadan between January 2000 and September 2011 were included in this study.
Other non-carcinomatous neoplasms of the stomach and all the cases of gastric carcinoma whose blocks and/or slides could not be retrieved were excluded from the study.
The demographic and clinical data of the gastric carcinoma patients diagnosed in the Pathology Department, UCH, Ibadan, in the above period were retrieved from the Cancer Registry, Pathology Department records and the Medical Records of the UCH and analysed for patients' age, gender, clinical presentation, histological diagnoses including tumour types (using the Lauren classification), stage, and presence of vascular permeation and/or lymph node status. Faded slides were re-stained and reviewed. Slides of cases which could not be retrieved were prepared from the archival (formalin-fixed, paraffin-embedded) samples of same patients and reviewed to confirm the histological diagnoses, histological types, stage and lymph node status.
All statistical analyses were performed with the Statistical Package for Social Sciences (SPSS) version 19. Student's chi square test was employed to define association between variables. However, when the expected count of any variable was less than 5, the Fisher's exact test was applied. The student's t-independent test was used to compare the mean age for gender and different histologic type of gastric carcinoma. The significant value was taken as P ≤ 0.05.
| Results|| |
A total of 117 cases of gastric carcinoma were diagnosed at the UCH, Ibadan, between January, 2000 and September, 2011, accounting for 1.38% of the 8467 cases malignancies from all body systems histologically diagnosed at the Pathology Department of the University College Hospital, Ibadan. It also accounted 18.4% of the 636 cases of gastrointestinal malignancies diagnosed within the same period.
Of these 117 cases, 74 (63.2%) were males and 43 (36.8%) were females, giving a male to female ratio of 1.72:1. About 63.5% of cases occurred between 41 and 70 years and the modal age-group of occurrence was 51-60 years [Figure 1] and [Table 1]. When the patients' ages were stratified into the social age-groups young (0-44 years), middle-age (45-64 years) and the elderly (65 years and above), the middle-age and the elderly accounted for 77.4% of the cases, while the young accounted for 22.6%.
|Figure 1: Bar chart showing the age distribution of gastric carcinoma patients diagnosed at the University College Hospital between the years 2000 and 2011|
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|Table 1: Age and sex distribution of gastric carcinoma patients diagnosed at the University College Hospital between the years 2000 and 2011|
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The mean, median and modal ages for all cases were 53.36 ± 15.31 years, 54.00 years and 50 years respectively. The mean and median ages for the male patients were 54.0 ± 15.30 and 53.0 years respectively, while those for the female patients were 52.24 ± 15.45 and 55 years respectively. There was no statistically significant difference between the mean ages of the male and female patients (P = 0.601, 95% confidence interval (CI) = −4.32-7.43).
The modal age-group for the males was 61-70 years group while that for the females was 51-60 years [Figure 2] and [Table 1]. The modal ages of the male and female groups are 50 years and 55 years respectively.
|Figure 2: Bar chart showing the age distribution of male and female gastric carcinoma patients diagnosed at the University College Hospital between the years 2000 and 2011|
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The commonest anatomical site for gastric carcinoma was the pylorus/antrum accounting for 80% (59/75 cases) of all anatomic sites, followed by the body and the fundus/cardia which accounted for 5.3% (4/75 cases) each [Table 2].
|Table 2: Anatomic site distribution of gastric carcinoma diagnosed at the UCH, ibadan between 2000 and 2011|
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In 2.7% of cases (2/75) the tumour involved more than one site, the pylorus/ antrum and either the fundus/cardia or the body. In 6.7% of cases (5/75) the anatomical site was not known [Table 2]. There was no association between the anatomical site of tumour and patients' age (P = 0.923), nor between the anatomical site of tumour and the patients' gender (P = 0.177).
The commonest macroscopic morphology of gastric carcinoma was exophytic (62.3%, 33/53), followed by ulcero-infiltrative (22.6%, 12/53) and flat/diffusely infiltrating (15.1%, 8/53) [Table 3]. No association was found between gross morphology of the tumour and patient's gender (P = 0.351), age (P = 0.805), or anatomic site of tumour (P = 0.262).
|Table 3: Frequency of the gross morphological types of gastric carcinoma diagnosed at the UCH, Ibadan between 2000 and 2011|
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The histological type of gastric carcinoma according to the Lauren classification was most commonly the intestinal type (47.0%, 55/117 cases). The diffuse type accounted for 35.1% (41/117) of cases, while the mixed/indeterminate type accounted for 17.9% (21/117) of cases [Table 4] and [Figure 3]. The mean age for the intestinal histotype of gastric tumour was 51.36 ± 15.24 years, 51.94 ± 16.61 years for the diffuse and 53.67 ± 16.17 years for the mixed histotype.
|Figure 3: Photomicrograph of intestinal (a and b), mixed (c and d) and diffuse (e and f) types of gastric carcinoma (Haematoxylin and Eosin).|
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|Table 4: Frequency of the histological types (Lauren classification) of gastric carcinoma diagnosed at the|
UCH, Ibadan between 2000 and 2011
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There was a significant association between the histological type of the tumour and the gross morphology of tumour (P = 0.002). Intestinal and mixed/indeterminate tumours were more likely to be exophytic or ulcero-infiltrative than tumours with diffuse histological morphology. Conversely, tumours with diffuse histological morphology had flat/diffusely infiltrating gross morphology than either exophytic or ulcero-infiltrative appearances.
There was no significant difference in the mean ages of patients with the different histological types of gastric carcinoma [intestinal versus mixed (P = 0.748), diffuse versus intestinal (P = 0.91) and diffuse versus mixed (P = 0.828)]. However, the commonest histological type of gastric cancer in the female patients was diffuse (16/43) as against intestinal (15/43) and mixed/indeterminate (12/43) in the male patients.
However, when the tumours were grouped into well-differentiated (mostly intestinal) and less differentiated grades (mostly diffuse and mixed), a significant association was found between grade and gender (P = 0.045) [Table 5]. Tumours from the female cohorts were likely to be less differentiated than tumours from their male counterparts.
|Table 5: Frequency of tumour grades of gastric carcinoma diagnosed at the UCH, Ibadan between 2000 and 2011|
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Of the 117 cases only in 69 cases could the extent of the disease be assessed from clinical records, request cards and histology reports of tumour. The disease was classified as either advanced or localised on the bases of depth of tumour invasion on histology, presence of lymph node and/or other metastases. On the basis of this classification, about 92.8% (64/69) of patients presented with advance disease. The disease was only localised in 7.2% (5/69) of cases in which the tumour was histologically limited to the mucosa or the muscularis propria. There was no significant association between the depth of invasion of the tumour and the other clinicopathological features of the tumours.
| Discussion|| |
The relative ratio frequency of 1.38% of gastric carcinoma found in this study is significantly lower than the figures of 2.73% and 3.6% (for the periods 1980-1988 and 1989-1996, respectively) obtained previously from the UCH by Ogunbiyi in 2000.  This reduction in frequency further supports the earlier assertion that there is a steady decline in the relative frequency of gastric carcinoma diagnosed in the Department of Pathology, UCH, Ibadan. , This decline may be due to an increase in pathological diagnosis of tumours from other sites rather than an absolute decrease in the incidence of gastric carcinoma. This relative frequency also falls outside the national relative frequency range of 1.64% and 4.1% found in other studies across the country over three decades, although it is nearly comparable to the 1.64% reported by Abdulkareem et al., from Lagos in 2010. ,,,
A rate of 18.4% for gastric carcinoma relative to other gastrointestinal tumours is somewhat higher than the 12% that was reported by Abdulkareem et al., in Lagos in 2009. 
In keeping with the fact that gastric carcinoma is predominantly a disease of middle age and the elderly, 77.4% of our cohort were 45-years-old and above. The overall mean age of patients found in this study is similar to what had previously been reported in Ibadan and elsewhere. Furthermore, when the patients were stratified into gender the modal age for male patients was 61-70 while that for the female was 51-60. This shows a tendency for the female gastric cancer patients to be younger than their male counterparts, although the difference in the median ages between the genders was not statistically significant.
The modal age-group found in this study is similar to what was reported in 2010 from three different centres (Lagos, Maiduguri and Ile-Ife). ,, It however, contrasts with the peak age incidences of the seventh to ninth decades obtained in studies from Japan, China, Korea, Australia, the United States [ ] and the United Kingdom. ,,,,,, The male predominance of 1.72:1 found in this study concurs withthe results of several other studies nationwide and worldwide. ,,,,,,,,,,,,,
This preponderance of pyloric/antral tumours was similarly reported by Oluwasola in Ibadan in 1998 accounting for 83.2% of gastric carcinomas in that study.  Pyloric/antral predominance was also reported from Ife, Maiduguri, and in Iran and the United States. ,,,,,
A significant association (P = 0.002) was found between the macroscopic growth pattern and the histological morphology of the tumour. This association has not been previously reported in local studies, probably because it had not been sought for in these other studies, and deserves to be considered in future studies of gastric cancer from this environment. ,,,,,[22
] The intestinal type of gastric carcinoma remains the commonest histological variant but in contrast to the rate of 56-88.7% found in previous studies, it occurs at a lower frequency of 47.0% in the present study. This difference represents a rise in the rate of the diffuse type of gastric carcinoma (35.1%) since the rate for the mixed/indeterminate histological type has remained generally constant (17-18.4%) over the past decade in Ibadan. This rise in the rate of the diffuse type of gastric carcinoma has similarly been reported in the United States over the past two decades and has been attributed to the relative fall in the intestinal type of gastric carcinoma globally. , The fall in the intestinal type of gastric carcinoma may be due to the widespread use of anti-H pylori treatment regimen for dyspeptic patients with chronic gastritis and peptic ulcer as this regimen has been shown to reverse precancerous lesions like chronic atrophic gastritis and intestinal metaplasia, which are associated with H pylori infection. 
There was also a significant association between tumour grade and the gross morphology of tumour. The flat or diffusely infiltrating tumours tended to be less differentiated than exophytic/ulcero-infiltrative tumours, while well-differentiated tumours are more likely to be exophytic/ulcero-infiltrative than flat. These associations have been classically described for gastric carcinoma. The better-differentiated gland-forming tumours typically form exophytic or ulcerated tumours, whereas, the poorly differentiated tumours composed mainly of discohesive cells, are diffusely infiltrating. ,,,
Contrary to the report by Abdulkareem et al., from Lagos in 2010, and Zheng et al., from Japan in 2007 where the diffuse histologic type of gastric carcinoma was significantly associated with the female gender, no association was found in this study between patients' gender and the histological type of gastric carcinoma (P = 0.056). , However, when the different histological types were re-grouped into well-differentiated (mostly intestinal type) and less differentiated (mostly diffuse and mixed) grades, the female gender was found to associate significantly with the less differentiated tumours (P = 0.045). Perhaps, the use of a larger sample size may have been able to clarify true relationship between gender and the Lauren's histological type of the tumour in our centre.
Similar to reports from several centres in Nigeria as well as from Western countries and Australia. ,, this study found that 92.8% of cases presented in advanced stage that confers poor prognosis to these tumours. ,,,
Although in recent times the prognosis of gastric cancer in Nigerian patients has improved significantly form the 5 year survival of 3% reported by Arigbagbu et al., in 1988 to about 14% (and up to 28.1% in those who had surgery with curative intent), this retrospective study does not report the follow-up characteristics of patients. ,, This is due to a high rate of loss of patients to follow-up as well as poor follow-up record keeping at the Medical Records Department. Under these circumstances the appropriate approach to obtain survival data for any study would have to be a prospective approach.
| Conclusions|| |
The clinicopathological characteristics of gastric carcinoma observed in this study are similar to what has been previously described except in the following regards: the lower relative ratio frequency of gastric carcinoma found in this study confirms the notion that there has been a steady, gradual decline in the relative rate of gastric carcinoma over the past three decades in Ibadan although they still make up a substantial proportion of all gastrointestinal malignancies in our centre. A rise in the diffuse histological type of gastric carcinoma, which has been reported in the United States over the past two decades, was now observed in this study.
| References|| |
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al
. (2013). GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr [Last accessed on 2014 Jun 27].
Abdulkareem FB, Onyekwere CA, Awolola NA, Ajekigbe AT. Clinicopathological study of malignant gastric tumours in Lagos. Nig Q J Hosp Med 2010;20:49-54.
Oluwasola AO, Ogunbiyi JO. Gastric cancers: Aetiological, clinicopathological and management patterns in Nigeria. Niger J Med 2003;12:177-86.
Abdulkareem FB, Faduyile FA, Daramola AO, Rotimi O, Banjo AA, Elesha SO, et al
. Malignant gastrointestinal tumours in south western Nigeria: A histopathologic analysis of 713 cases. West Afr J Med 2009;28:173-6.
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al
. Cancer Statistics, 2008. CA Cancer J Clin 2008;58:71-96.
Garcia M, Jemal A, Ward EM, Center MM, Hao Y, Siegel RL, et al
. Global Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society, 2007. Available from: http://www.nostomachforcancer.org/gastric-cancer/stomach-cancer-statistics [Last accessed on 2011 May 7].
Bakari AA, Ibrahim AG, Gali BM, Dogo D, Ngadda HA. Pattern of gastric cancer in north-eastern Nigeria: A clinicopathologic study. J Chin Clin Med 2010;5:211-5.
Ogunbiyi JO. Epidemiology of cancer in Ibadan: Tumours in adults. Arch Ibadan Med 2000;1:9-12.
Oluwasola AO, Ogunbiyi JO. Helicobacter pylori-associated gastritis and gastric cancer in Nigeria. Indian J Gastroenterol 2003;22:212-4.
Sabageh D, Ojo OS, Adelusola KA. Gastric carcinoma: A review of the histopathologic features of cases seen at Ile-Ife, Nigeria. Ann Trop Pathol 2010;1:27-34.
Theuer CP, Campbell BS, Peel DJ, Lin F, Carpenter P, Ziogas A, et al
. Microsatellite Instability in Japanese versus European American Patients with gastric cancer. Arch Surg 2002;137:960-5.
Lee HJ, Yang HK, Ahn YO. Gastric cancer in Korea. Gastric Cancer 2002;5:177-82.
Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol 2006;12:17-20.
Australian Institute of Health and Welfare (AIHW) and Australasian Association of Cancer Registries (AACR) 2001. Cancer survival in Australia, 2001. Part 1: National summary statistics. AIHW cat. no. CAN 13. Canberra: Australian Institute of Health and Welfare (Cancer Series No. 18). p. 20-3.
Cabebe EC, Mehta VK. Gastric cancer. Updated December 7, 2010 Available from: http://emedicine.medscape.com/article/278744-overview [Last accessed on 2011 Jan 16].
Cancer Statistics for the UK. Stomach cancer-UK incidence. Updated June 10, 2010. Available from: http://info.cancerresearchuk.org/ cancerstats/ incidence [Last accessed on 2011 Jan 16].
Komolafe AO, Ojo OS, Olasode BJ. Gastric malignancies and associated pre-malignant lesions in a teaching hospital in South West Nigeria. Afr J Biotech 2008;7:2104-11.
Oluwasola AO. The role of Helicobacter pylori in chronic gastritis and gastric cancer: A histopathologic review of cases seen in Ibadan between January 1980 and May 1997. Part II research dissertation to the West African College of Physicians in the faculty of Laboratory Medicine, October; 1998.
Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J 2005;81:419-24.
Abdi-Rad A, Ghaderi-sohi S, Nadami-Barfroosh H, Emami S. Trends in incidence of gastric adenocarcinoma by tumour location from 1969-2004: A study in one referral centre in Iran. Diagn Pathol 2006;1:5.
Wu H, Rusiecki JA, Zhu K, Potter J, Devesa SS. Stomach Carcinoma Incidence patterns in the United States by histologic type and anatomic site cancer. Cancer Epidemiol Biomarkers Prev 2009;18:1945-52.
Turner JR. The Gastrointestinal Tract. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran Pathologic Basis of Diseases. 8 [th]
ed. Philadelphia: Saunders Elsevier; 2010. p. 763-831.
Rosai J, ed. Rosai and Ackerman's Surgical Pathology. 9 [th]
ed. New York: Elsevier; 2004. Chapter 11, Gastrointestinal Tract; Vol 1, p. 648-711.
Correa P, Piazuelo MB, Wilson KT. Pathology of gastric intestinal metaplasia: Clinical implications. Am J Gastroenterol 2010;105:493-8.
Campbell F, Bogomoletz V, William GT. Tumours of Oesaphagus and stomach. In: Fletcher CD, editor. Diagnostic Histopathology of Tumours. 2 [nd]
ed. Boston: Churchill Livingstone 2000;1:332-9.
Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, et al
. Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: An immunostaining study on the tissue microarray. J Clin Pathol 2007;60:273-7.
Carl-McGrath S, Ebrt M, Rocken C. Gastric carcinoma: Epidemiology, pathology, and pathogenesis. Cancer Ther 2007;5:877-94.
Arigbagbu AO. Gastric cancer in Nigeria. Trop Doct 1988;18:13-5.
Alatise OI, Lawal OO, Adesunkanmi AK, Agbakwuru AE, Arigbabu OA, Ndububa DA, et al
. Clinical pattern and management of gastric cancer in Ile-Ife, Nigeria. Arab J Gastroenterol 2007;8:123-6.
Ahmed A, Ukwenya AY, Makama JG, Mohammad I. Management and outcome of gastric carcinoma in Zaria, Nigeria. Afr Health Sci 2011;11:353-61.
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]