|Year : 2017 | Volume
| Issue : 3 | Page : 96-100
Sexual functioning and health-related quality of life in men
Patricia A Agaba1, Amaka N Ocheke2, Maxwell O Akanbi3, Zumnan M Gimba4, Jennifer Ukeagbu4, Benjamin D Mallum4, Emmanuel I Agaba3
1 Department of Family Medicine, University of Jos, Jos, Nigeria
2 Department of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria
3 Department of Internal Medicine, University of Jos, Jos, Nigeria
4 Department of Internal Medicine, Jos University Teaching Hospital, Jos, Nigeria
|Date of Web Publication||11-Jun-2018|
Dr. Emmanuel I Agaba
Department of Internal Medicine, University of Jos, Jos
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Background: Although erectile dysfunction (ED) is common, little is known about the impact of ED on the quality of life (QoL) among African men. Materials and Methods: We used the International Index of Erectile Function (IIEF) to evaluate ED and the WONCA charts to assess QoL among employees of a university. Results: A total of 508 men with a mean age of 43 ± 10 years were studied. IIEF5 scores of <22 were present in 406 participants (77.9%). Mild ED, mild-to-moderate ED, moderate ED, and severe ED were present in 34.6%, 26.6%, 10.4%, and 5.7%, respectively. Systolic and diastolic blood pressure were significantly lower in those with ED. Marital status, alcohol, cigarette, physical inactivity, obesity, hypertension, diabetes mellitus, and antihypertensive drug use were not associated with ED. ED was associated with poor QoL in the domains of social activities (odds ratio [OR] = 4.35; 95% confidence interval [CI]: 1.01–18.7), and overall health (OR = 2.27; 95% CI: 1.07–4.82). However, there was no association of ED with poor QoL in the domains of physical fitness (OR = 1.46; 95% CI: 0.82–2.59), feelings (OR = 1.43; 95% CI: 0.75–2.72), daily activities (OR = 4.72; 95% CI: 0.61–36.4), and change in health (OR = 1.75; 95% CI: 0.58–5.26). Conclusion: ED negatively impacts QoL in men.
Keywords: Erectile dysfunction, impotence, quality of life, social functioning
|How to cite this article:|
Agaba PA, Ocheke AN, Akanbi MO, Gimba ZM, Ukeagbu J, Mallum BD, Agaba EI. Sexual functioning and health-related quality of life in men. Niger Med J 2017;58:96-100
|How to cite this URL:|
Agaba PA, Ocheke AN, Akanbi MO, Gimba ZM, Ukeagbu J, Mallum BD, Agaba EI. Sexual functioning and health-related quality of life in men. Niger Med J [serial online] 2017 [cited 2018 Dec 18];58:96-100. Available from: http://www.nigeriamedj.com/text.asp?2017/58/3/96/234077
| Introduction|| |
The inability to achieve and/or maintain penile erection adequate for penetrative sex is regarded as erectile dysfunction (ED). ED is common and has been well characterized in the western world, occurring in up to 40%–52% of men above 40 years of age., The literature is replete with studies documenting the prevalence of ED among patient populations in Nigeria., Available data from community surveys suggest that up to 43.8% of men in the community have ED., Studies have shown that while many men with ED desire treatment, few seek medical attention as many are uncomfortable discussing sex even in the western world.,
ED has been shown to affect quality of life (QoL) in several populations, both in patients with chronic illnesses and apparently healthy individuals.,,,[12 Little, however, is known about the impact of ED and QoL in indigenous African men  as it is generally believed that Africans do not talk about sex. We hypothesize that because men do not readily seek medical help for ED, it does not impact on their QoL. In this cross-sectional study of males employed in a university, we determined the prevalence and correlates of ED. We also explored its impact on health-related QoL.
| Materials and Methods|| |
This cross-sectional study was conducted as part of a larger study to evaluate the burden of noncommunicable diseases and their risk factors among employees of the University of Jos. Approval for the study was obtained from the Human Research Ethics Committee of the Jos University Teaching Hospital. Informed written consent was obtained from all the men before recruitment, and their identifiers were removed from data and confidentiality maintained.
Male staff members of the university aged >18 years were invited to present themselves at the University Health Clinic for the study. Invitations were sent to all units, departments, and institutes of the university. Posters of invitation were also circulated within the university and adverts placed on the University of Jos Radio Station. Information on sociodemographics, social habits, and history of hypertension and diabetes mellitus (DM) was obtained using a case-record form. The abridged version of the International Index of Erectile Function-5 (IIEF-5) questionnaire  was investigator administered on the participants to obtain information on sexual functioning. This instrument assesses sexual functioning in the domains of erectile function and intercourse satisfaction. This questionnaire has been used in studies on ED in Nigeria.,, Responses to this questions are graded on a 5-point ordinal scale of 1–5 with “1” being the worst and “5” the best possible, respectively. The Dartmouth COOP/WONCA charts  were investigator administered to assess the QoL of the participants. These charts evaluated the QoL in the domains of physical functioning, emotional functioning, activities of daily living, social activities, changes in health, and overall health in the preceding 2 weeks. Responses are graded on a 5-point ordinal scale with “1” as best and “5” as worst.
Physical measurements conducted on each participant included height (m), body weight (kg), and waist circumference (WC, cm). WC was measured using a nonelastic measuring tape at mid-point between the subcostal margin and the upper border of the iliac crest. The body mass index was calculated using the Quetelet index. Blood pressure (BP) measurements were taken using an electronic sphygmomanometer (OMRON) after participants were first made to sit quietly for at least 5 min in a chair (rather than on an examination table) with their backs supported and their arms bared and supported at heart level. Three readings of each participant's BP were taken and the last two measurements averaged as the participant's BP. Two milliliters of venous blood was taken from the antecubital vein for blood glucose determination.
Hypertension, DM, generalized obesity, and central obesity were defined using internationally accepted guidelines.,,, ED was defined as IIEF-5 score <22 with scores of 1–7 as severe ED, 8–11 as moderate ED, 12–16 as mild-to-moderate ED, and 17–21 as mild ED.
QoL was stratified into “good” when the score on each domain was 1 or 2, “acceptable” for a score of “3,” and “poor” for scores of “4” or “5.” For statistical analysis, QoL was further transformed into a dichotomous variable as “high QoL” or “low QoL” for scores of “1–2” and “3–5,” respectively. Data were analyzed using Epi Info 7 (CDC, Atlanta, GA). Uniformly distributed continuous variables were presented as means ± standard deviation while nonuniformly distributed ones as medians (interquartile range). Discrete variables were presented as proportions. Chi-square test was used to compare the significance of observed differences between proportions and the Student t-test to compare group means. Where cells contained less than five observations, the Fisher's exact test was used. Odds ratios (OR) (with 95% confidence interval [CI]) were calculated to evaluate the association of ED and QoL. P < 0.05 was considered significant.
| Results|| |
Characteristics of subjects
A total of 508 men with a mean age of 43 ± 10 years were studied. The majority were married (88.4%), junior cadre workers (61.2%), and lacked tertiary education (91.7%). [Table 1] shows the sociodemographic and anthropometric measurements of the participants.
|Table 1: Characteristics of 508 male employees screened for erectile dysfunction using the International Index of Erectile Function.5|
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Prevalence of erectile dysfunction
ED (IIEF5 scores of <22) was present in 406 participants (77.4%). Mild ED, mild-to-moderate ED, moderate ED, and severe ED was present in 44.8%, 34.4%, 13.5%, and 7.4%, respectively. We examined severity of ED across different age groups and found a significant difference in ED severity (P = 0.0002). Participants aged 31–40 years had the highest proportion of severe ED while the 61–70 years' age group had the highest proportion of moderate ED [Figure 1].
|Figure 1: Relationship of age to severity of erectile dysfunction in 508 male university workers (χ = 44.7; P = 0.0002). ED = Erectile dysfunction|
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Determinants of erectile dysfunction
Participants with and without ED were similar with respect to sociodemographic characteristics and anthropometric measurements [Table 1]. Taken separately, systolic and diastolic BPs were significantly lower in those with ED. However, hypertension was not associated with ED in logistic regression model [Table 2]. Similarly, older age (>45 years) marital status, alcohol, cigarette, physical inactivity, obesity, DM, and antihypertensive drug use were not associated with ED.
|Table 2: Independent predictors of erectile dysfunction in 508 male employees of the University of Jos|
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To assess the determinants of ED, first, we fitted a logistic model with individual variables and found none to be predictive of ED [Table 2]. Second, we created composite risk groups based on documented risk factors to check if having more than one risk factors might predict ED as follows: risk group 1 – metabolic group (obesity, hypertension, and diabetes), risk group 2 – lifestyle (alcohol use, smoking, and physical inactivity), and risk group 3 – sociodemographic (age >45 years, marital status, and level of education.). None of the risk groups was predictive of ED on logistic regression. However, when we stratified ED by severity (none severe ED = mild/mild-moderate versus severe ED-moderate/severe) and used this dichotomized variable as a dependent outcome, with the same risk factors as independent variables, being married reduced the risk of severe ED by 79% (adjusted OR = 0.21, 95% CI: 0.11–0.38), with other variables not demonstrating significant relationships [Table 3].
|Table 3: Independent predictors of severe erectile dysfunction in 508 male employees of the University of Jos|
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Impact of erectile dysfunction on quality of life
Data on QoL were available on 356 men. The men who had and did not have data on QoL were similar in terms of sociodemographic parameters and anthropometric measurements except in the proportion who were obese (P = 0.04). ED was associated with poor QoL in the domains of social activities (OR = 4.35; 95% CI: 1.01–18.7) and overall health (OR = 2.27; 95% CI: 1.07–4.82). However, there was no association of ED with poor QoL in the domains of physical fitness (OR = 1.46; 95% CI: 0.82–2.59), feelings (OR = 1.43; 95% CI: 0.75–2.72), daily activities (OR = 4.72; 95% CI: 0.61–36.4), and change in health (OR = 1.75; 95% CI: 0.58–5.26).
| Discussion|| |
ED may significantly affect the QoL in men. We studied the prevalence of ED and its impact on the QoL among men working in a university. We found that ED is highly prevalent with the younger men experiencing severe forms of ED. In addition, ED impacted negatively on the social and overall health domains of QoL.
We found a high prevalence of ED among the participants of this study. ED prevalence rates as high as that reported in this study have been documented among patients with chronic illnesses.,, However, lower figures have been reported in individuals without chronic illnesses.,,, The wide variation in the prevalence of ED in these studies may be due to differences in methodologies, participant selection, and subjective experiences.
The younger age group in this study (31–40 years) reported the highest prevalence of severe ED. This is contrary to findings in other studies where older age has been associated with the more severe forms of ED.,,,, The participants in our study were highly educated and made up of relatively young men at the prime of sexual activity and may have over-reported their perceptions of ED symptoms. In addition to age, other factors that have been associated with ED in previous studies include alcohol intake, cigarette smoking, low socioeconomic status, length of marriage, obesity, hypertension, diabetes, and depression among others.,,, We did not find an independent relationship between ED and age, BP, DM, alcohol use, cigarette smoking, or use of antihypertensive medications. The reason for the disparity between our study findings and that of previous reports is not apparent and left to conjecture.
Previous studies have found that ED impacts negatively on the QoL.,,, ED was significantly associated with poor social functioning and overall health quality in our participants. While our finding confirms that of Litwin et al., who found that ED impacted on the perception of overall health quality and not on the physical domain, it differs from theirs with regard to its impact on the social domain. They found that ED impacted negatively on the emotional domain and not the social domain. Similarly, Idung et al. reported that social functioning and psychological health indicators of QoL were severely impaired in men with ED. Our study differs from theirs in both methodology and participant characteristics.
Our study had some limitations that may hamper the generalizability of our findings. The participants in this study were highly selected and may not be representative of the general community. However, the choice to study university workers was to avoid the need for back to back translation as all the participants had formal education with 18% having tertiary education. Another limitation is the subjective nature of the tool used in assessing ED as IIEF assesses sexual experience over the past 6 months and hence is subject to recall bias. We were unable to verify the assertions of the participants. Finally, given the cross-sectional design of the study, we could not establish a cause and effect relationship between ED and QoL. Despite the foregoing, ours is one of the few studies assessing the impact of ED on QoL in our environment and provides data on this subject matter.
Our findings have implications for health-care services for men. Given the high prevalence of ED and the fact that men with ED find it difficult to seek treatment,, physicians should actively seek for symptoms of ED when offering health-care services to men. Physicians should also be aware of the poor social functioning and poor overall health that is associated with ED.
We conclude that ED is highly prevalent among male workers of a university in Nigeria. Our study also demonstrated that ED impacts negatively on the social well-being and the overall health quality of this group of individuals. There is the need for community studies to elucidate the magnitude of the problem.
This study was funded in part by the Tertiary Education Trust Fund of the Federal Government of Nigeria. The authors acknowledge the contribution of the management of the University Health Centre and the leaders and members of the various associations in the University of Jos for participating in the study. We also appreciate the efforts of the physicians who participated in data collection and Mr Chime of the Jos University Teaching Hospital for data entry.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Bai Q, Xu QQ, Jiang H, Zhang WL, Wang XH, Zhu JC, et al.
Prevalence and risk factors of erectile dysfunction in three cities of China: A community-based study. Asian J Androl 2004;6:343-8.
Levy J. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
Idung AU, Abasiubong F, Ukott IA, Udoh SB, Unadike BC. Prevalence and risk factors of erectile dysfunction in niger delta region, Nigeria. Afr Health Sci 2012;12:160-5.
Okeahialam BN, Obeka NC. Erectile dysfunction in nigerian hypertensives. Afr J Med Med Sci 2007;36:221-4.
Olugbenga-Bello AI, Adeoye OA, Adeomi AA, Olajide AO. Prevalence of erectile dysfunction (ED) and its risk factors among adult men in a Nigerian community. Niger Postgrad Med J 2013;20:130-5. [Full text]
Fatusi AO, Ijadunola KT, Ojofeitimi EO, Adeyemi MO, Omideyi AK, Akinyemi A, et al.
Assessment of andropause awareness and erectile dysfunction among married men in ile-ife, Nigeria. Aging Male 2003;6:79-85.
Mohammad-Alizadeh Charandabi S, Mirghafourvand M, Khaki-Rostami Z, Malakouti J, Asghari Jafarabadi M, Ghanbari-Homayi S, et al.
Sexual dysfunction and help seeking behaviors in newly married men in Sari City: A Descriptive. J Caring Sci 2015;4:143-53.
Buvat J, Glasser D, Neves RC, Duarte FG, Gingell C, Moreira ED Jr., et al.
Sexual problems and associated help-seeking behavior patterns: Results of a population-based survey in France. Int J Urol 2009;16:632-8.
De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, et al.
Erectile dysfunction and quality of life in type 2 diabetic patients: A serious problem too often overlooked. Diabetes Care 2002;25:284-91.
Martín-Díaz F, Reig-Ferrer A, Ferrer-Cascales R. Sexual function and quality of life in hemodialysis male patients. Nefrologia 2006;26:452-60.
Rosas SE, Joffe M, Franklin E, Strom BL, Kotzker W, Brensinger C, et al.
Association of decreased quality of life and erectile dysfunction in hemodialysis patients. Kidney Int 2003;64:232-8.
Litwin MS, Nied RJ, Dhanani N. Health-related quality of life in men with erectile dysfunction. J Gen Intern Med 1998;13:159-66.
Idung AU, Abasiubong F, Udoh SB, Akinbami OS. Quality of life in patients with erectile dysfunction in the Niger Delta Region, Nigeria. J Ment Health 2012;21:236-43.
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM. Development and evaluation of an abridged, 5-item version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319-26.
Van Weel C. Functional status in primary care: COOP/WONCA charts. Disabil Rehabil 1993;15:96-101.
Eknoyan G. Adolphe quetelet (1796-1874) – The average man and indices of obesity. Nephrol Dial Transplant 2008;23:47-51.
Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al
. 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34:2159-219.
World Health Organization. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. Production 2006. Available from: www.who.int/diabetes/.../Definition%20and%20diagnosis%20of%20diabetes_new.pdf. [Last accessed on 2014 Jun 14].
International Diabetes Federation. The IDF Consensus Worldwide Definition of the Metabolic Syndrome. Vol. 28. 2006. p. 1-7.
Fafiolu AS, Adebayo AM, Akande TO, Akinboboye OO. Erectile dysfunction among male hypertensives in a tertiary health facility in South-West Nigeria. Glob J Health Sci 2014;7:154-60.
Olarinoye JK, Kuranga SA, Katibi IA, Adediran OS, Jimoh AA, Sanya EO, et al.
Prevalence and determinants of erectile dysfunction among people with type 2 diabetes in Ilorin, Nigeria. Niger Postgrad Med J 2006;13:291-6.
Malekmakan L, Shakeri S, Haghpanah S, Pakfetrat M, Sarvestani AS, Malekmakan A, et al.
Epidemiology of erectile dysfunction in hemodialysis patients using IIEF questionnaire. Saudi J Kidney Dis Transpl 2011;22:232-6.
] [Full text]
Adebusoye LA, Olapade-Olaopa OE, Ladipo MM, Owoaje ET. Prevalence and correlates of erectile dysfunction among primary care clinic attendees in Nigeria. Glob J Health Sci 2012;4:107-17.
Oladiji F, Kayode OO, Parakoyi DB. Influence of socio-demographic characteristics on prevalence of erectile dysfunction in Nigeria. Int J Impot Res 2013;25:18-23.
Okulate G, Olayinka O, Dogunro AS. Erectile dysfunction: Prevalence and relationship to depression, alcohol abuse and panic disorder. Gen Hosp Psychiatry 2003;25:209-13.
Amini Lari M, Faramarzi H, Shams M, Marzban M, Joulaei H. Sexual dysfunction, depression and quality of life in patients with HIV infection. Iran J Psychiatry Behav Sci 2013;7:61-8.
[Table 1], [Table 2], [Table 3]