%A Awe, Oluwaseun %A Onakpoya, Oluwatoyin %A Adeoye, Adenike %T Effect of long-term topical antiglaucoma medication use on the ocular surface %9 Original Article %D 2020 %J Nigerian Medical Journal %R 10.4103/nmj.NMJ_116_19 %P 184-188 %V 61 %N 4 %U https://www.nigeriamedj.com/article.asp?issn=0300-1652;year=2020;volume=61;issue=4;spage=184;epage=188;aulast=Awe %8 July 1, 2020 %X Purpose: The purpose of this study was to describe the prevalence and pattern of ocular surface disease (OSD) in glaucoma patients using preserved topical antiglaucoma medications in a Nigerian population. Methodology: A comparative study of patients who had used topical preserved antiglaucoma medications for 6 months or more with age- and sex-matched individuals who were not on any other form of topical eye medication was carried out using fluorescein tear breakup time (FTBUT), Schirmer I test, and ocular surface staining with fluorescein and lissamine green. The right eyes of 103 eligible patients with primary open-angle glaucoma and that of 103 age- and sex-matched individuals (controls) were included in the study. Results: The prevalence of OSD among users of preserved topical antiglaucoma medications was significantly higher than among nonusers as assessed by FTBUT (83.5% vs. 57.3%;P < 0.001), Schirmer I (30.1% vs. 17.5%; P = 0.033), and ocular surface staining (62.1% vs. 31.1%;P < 0.001). Users of preserved topical antiglaucoma medications also had worse grades of OSD evaluated by FTBUT (P = 0.001), Schirmer I (P = 0.023), and ocular surface staining (P < 0.001). Conclusion: The prevalence of subjective OSD was significantly higher among users of topical antiglaucoma medications than nonusers. Hence, preserved topical medication use is a serious concern for increased ocular surface morbidity among glaucoma patients. This calls for more attention to be paid to the consequences of OSD among glaucoma patients on topical medications. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0300-1652