Nigerian Medical Journal

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 55  |  Issue : 5  |  Page : 428--431

Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis


Kehinde Sola Akinlade1, Christiana Odunayo Adewale1, Sheu Kadiri Rahamon1, Foluke Atinuke Fasola1, John Ayodele Olaniyi2, Adedeji David Atere1 
1 Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria
2 Department of Haematology, University of Ibadan/University College Hospital, Ibadan, Nigeria

Correspondence Address:
Kehinde Sola Akinlade
Metabolic Research Unit, Department of Chemical Pathology, University of Ibadan/ University College Hospital, Ibadan, 200212
Nigeria

Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as in other haematological disorders. However, there is little information on the lipid profile of SCA subjects in vaso-occlusive crisis (VOC). This study determined the lipid profile of adult SCA subjects in VOC and in steady state (SSCA). Materials and Methods: Fifty-eight (58) adults with HbSS (30 in steady state and 28 in vaso-occlusive crisis) and 24 age-matched healthy individuals with HbAA genotype were recruited into this study. Standard methods were used for the determination of blood pressure (BP), packed cell volume (PCV), total white blood cell count (WBC) and haemoglobin phenotype. After an overnight fast, 5 ml of venous blood was obtained from each SSCA and the controls while samples were collected upon admission in the VOC group. Plasma lipid profile was determined using enzymatic method. Differences between two groups were determined using independent Student�SQ�s t-test or Man-Whitney U as appropriate. P-values less than 0.05 were considered significant. Results: Plasma total cholesterol (TC) and high density lipoprotein (HDL) were significantly lower while the ratio of triglyceride (TG) to HDL (TG/HDL) was significantly higher in SSCA compared with the controls. Low density lipoprotein (LDL) and TC were significantly lower in SCA subjects in VOC compared with controls. However, TC, TG, LDL and TG/HDL were significantly lower while HDL was significantly higher in VOC compared with SSCA. Conclusion: Sickle cell anaemia subjects have defective fasting lipid metabolism which becomes pronounced with VOC.


How to cite this article:
Akinlade KS, Adewale CO, Rahamon SK, Fasola FA, Olaniyi JA, Atere AD. Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis.Niger Med J 2014;55:428-431


How to cite this URL:
Akinlade KS, Adewale CO, Rahamon SK, Fasola FA, Olaniyi JA, Atere AD. Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis. Niger Med J [serial online] 2014 [cited 2024 Mar 28 ];55:428-431
Available from: https://www.nigeriamedj.com/article.asp?issn=0300-1652;year=2014;volume=55;issue=5;spage=428;epage=431;aulast=Akinlade;type=0