Nigerian Medical Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 60  |  Issue : 2  |  Page : 47--52

Fallopian tube epithelial changes in ovarian serous tumors compared with control group: A single-center study


Fatemeh Sari Aslani1, Mona Maleknasab2, Mojgan Akbarzadeh-Jahromi1 
1 Department of Pathology, Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Dr. Mojgan Akbarzadeh-Jahromi
Department of Pathology, Maternal-Fetal Medicine Research Center, Medical School, Shiraz University of Medical Sciences, P. O. Box: 71345-1864, Shiraz
Iran

Background: Recent studies have hypothesized that distal end of fallopian tube is a possible origin of ovarian serous carcinoma. This study investigated histopathological changes in fallopian tube epithelium (FTE) of the patients with ovarian serous tumors compared with control group. Materials and Methods: In a prospective cross-sectional study, fallopian tubes (right and left) of 34 cases with ovarian serous tumors were collected from patients who underwent surgery in two major gynecological centers affiliated to Shiraz University of Medical Sciences, Shiraz, Iran (2012–2015). They are composed of 21 (61.8%) high-grade serous carcinomas (HGSCs), 5 (14.7%) borderline ones, and 8 (23.5%) benign serous tumors. As control group, fallopian tubes of 72 hystrectomy cases without ovarian tumor were added to the study. Both tubes of all of the cases were submitted entirely, according to the protocol of sectioning and extensively examining the fimbriated end. The results were statistically analyzed using SPSS-PC windows and Chi-square tests. Results: Significant differences were found between the cases and control group in tubal epithelial cell stratification (especially >3 cell layers thickness), atypia, mitosis, glandular complexity, tufting, and detached epithelial cells (P < 0.05). These findings particularly atypia and mitosis were more frequently seen in the ampulla and fimbriated end of high-grade ovarian serous carcinomas. Conclusion: Our results showed that premalignant epithelial changes of the ampulla and the distal end of FTE were seen in some of the patients with ovarian HGSCs. Therefore, FTE could be one of the sources of ovarian serous carcinoma.


How to cite this article:
Aslani FS, Maleknasab M, Akbarzadeh-Jahromi M. Fallopian tube epithelial changes in ovarian serous tumors compared with control group: A single-center study.Niger Med J 2019;60:47-52


How to cite this URL:
Aslani FS, Maleknasab M, Akbarzadeh-Jahromi M. Fallopian tube epithelial changes in ovarian serous tumors compared with control group: A single-center study. Niger Med J [serial online] 2019 [cited 2019 Dec 13 ];60:47-52
Available from: http://www.nigeriamedj.com/article.asp?issn=0300-1652;year=2019;volume=60;issue=2;spage=47;epage=52;aulast=Aslani;type=0