Hyper-reactive malarial splenomegaly: A case report and review of the management and pathogenesis
IJ Emodi, AN Ikefuna
Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria
I J Emodi Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu Nigeria
Source of Support: None, Conflict of Interest: None
Hyper-reactive malarial splenom egaly is thought to represent a dysfunctional immune response to recurrent malaria infection. A 14 year old male child with hms, hypersplenism, ascites and peripheral lymphadenopathy is reported. There was initial poor response to proguanil aggravated by non compliance. He was started on a combination of proguanil and chloroquine with counseling and showed good and fast response. A review of the management and recent concept of pathogenesis is presented.