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Year : 2009  |  Volume : 50  |  Issue : 4  |  Page : 97-99

Hyper-reactive malarial splenomegaly: A case report and review of the management and pathogenesis

Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria

Correspondence Address:
I J Emodi
Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu
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Source of Support: None, Conflict of Interest: None

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Hyper-reactive malarial splenom egaly is thought to represent a dysfunctional immune response to recurrent malaria infection. A 14 year old male child with hms, hypersplenism, ascites and peripheral lymphadenopathy is reported. There was initial poor response to proguanil aggravated by non compliance. He was started on a combination of proguanil and chloroquine with counseling and showed good and fast response. A review of the management and recent concept of pathogenesis is presented.

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