Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Users Online: 787


Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Advertise Contacts Login 
Year : 2014  |  Volume : 55  |  Issue : 1  |  Page : 63-66

Prevalence of HIV-related autoimmune haemolytic anaemia in Lagos, Nigeria

1 Department of Haematology and Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria
2 Department of Haematology and Blood Transfusion, Faculty of Basic Medical Sciences, Lagos State University, College of Medicine, Ikeja, Nigeria
3 Department of Haematology and Blood Transfusion, Jos University Teaching Hospital, Jos, Nigeria

Correspondence Address:
A Adediran Adewumi
Department of Haematology and Blood Transfusion, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0300-1652.128175

Rights and Permissions

Background: Despite a high frequency of anaemia, a positive direct antiglobulin test (DAT) and bone marrow hyperplasia HIV-infected patients, lack of reticulocytosis may cause underdiagnosis autoimmune haemolytic anaemia (AIHA) in them. This study was carried out to determine the prevalence of autoimmune haemolytic anaemia in HIV-infected patients and to compare the haematological/immunological characteristics of subjects with anaemia and those without. Materials and Methods: A total of 350 HIV-infected subjects attending the Lagos University Teaching Hospital who consented were recruited for the study. This included 250 subjects with anaemia (haemoglobin concentration <10 g/dl) as cases and 100 subjects without anaemia as controls. Five milliliters of venous blood drawn from each subject was used for the full blood count, reticulocyte count and DAT. Results: Subjects with anaemia had lower mean CD4 cell count (284.3 cells/μl) and higher mean reticulocyte per cent (1.5%) than the non-anaemic subjects. The frequency of reticulocytosis was higher in female subjects than in males. Only 0.8% (2 of 250) of the study group screened positive to DAT, p = 0.0339. None of the subjects in control group screened positive to DAT. Conclusion: Autoimmune haemolytic anaemia is a rare complication of HIV infection in our geographical location.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded130    
    Comments [Add]    
    Cited by others 1    

Recommend this journal