| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 57
| Issue : 2 | Page : 114-118 |
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Evaluation of oxidant-antioxidant balance and total antioxidant capacity of serum in children with urinary tract infection
Gholamreza Soleimani1, Simin Sadeghi-Bojd1, Alireza Teimouri2, Alireza Nakhaee3, Alireza Sheikhhosseini4
1 Department of Pediatrics, School of Medicine, Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2 Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
3 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4 Department of Pediatrics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Correspondence Address:
Simin Sadeghi-Bojd
Department of Pediatrics, School of Medicine, Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0300-1652.182073
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Background: Urinary tract infection (UTI) is the most common bacterial infections in children. This studyaimed to investigate the oxidative and antioxidate status of plasma in patients with UTI and to compare them with those of the controls. Methods: This case–control study of 50–75 children in the given order was performed in 2013 at the Pediatric Clinic of infections in Zahedan Hospital of Ali Ibn Abi Talib. The antioxidative status of plasma were evaluated by measuring the total antioxidant capacity (TAC) The oxidative status of samples was assessed by measuring the total peroxide and the oxidative stress index (OSI) levels. The means of the parameters were compared and the relationship among them was determined. Data were analyzed using SPSS 20 (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp). Student's t-test and Mann–Whitney U-test were applied in various situations of our questions; 95% confidence interval was considered for the level of significance. Results: The results showed that total oxidant serum status in UTI patients was higher compared to controls when total antioxidant serum was lower. The balance of oxidant-antioxidant serum was in favor of oxidant serum and this term was confirmed by OSI. Conclusion: Our results showed that the plasma levels of TAC in patients with UTI were decreased compared to controls, and oxidant-antioxidant balance and OSI caused increased OS in patients. |
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