| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 57
| Issue : 2 | Page : 119-123 |
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Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient
Sunita Neupane1, Raju Kumar Dubey1, Narayan Gautam1, Krishna Kumar Agrawal2, Archana Jayan1, Sujata Shrestha1, Amit Chandra Jha1
1 Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal
2 Department of Internal Medicine, Universal College of Medical Sciences, Bhairawaha, Nepal
Correspondence Address:
Raju Kumar Dubey
Universal College of Medical Sciences, Bhairahawa
Nepal
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0300-1652.182074
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Background: Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Poor glycemic control leads to diabetic complications. Hyperuricemia has been reported with increased risk of renal insufficiency. The aim of this study was to evaluate the relationship between serum uric acid concentration, degree of urinary albumin excretion (UAE) and glycated hemoglobin (HbA1c) in Type 2 DM (T2DM) patients. Materials and Methods: Serum uric acid concentrations, urine microalbumin, and HbA1c were measured in fifty T2DM patients. We then evaluated relationship between uric acid concentrations, degree of UAE and glycemic control as well as other confounding variables. Results: Serum uric acid concentration correlated positively with UAE (r = 0.323, P < 0.05), age (r = 0.337, P < 0.05), age at onset (r = 0.341, P < 0.05), and duration of DM (r = 0.312, P < 0.05). Multiple regression analysis demonstrated that serum uric acid concentration (<β = 0.293, P < 0.0001), duration of DM (<β = 0.261, P < 0.0001), HbA1c (<β = 0.173, P < 0.005), and systolic blood pressure (<β = 0.268, P < 0.005) were independent determinants of UAE. Conclusions: Serum uric acid concentration is associated with microalbuminuria and HbA1c in T2DM patients. |
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