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ORIGINAL ARTICLE
Year : 2016  |  Volume : 57  |  Issue : 6  |  Page : 347-352

Gentamicin-mediated ototoxicity and nephrotoxicity: A clinical trial study

Parviz Saleh1, Shamsi Abbasalizadeh2, Saman Rezaeian3, Mohammad Naghavi-Behzad4, Reza Piri5, Hojjat Hossein Pourfeizi6
1 Chronic Kidney Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Ear, Nose and Throat (ENT), Tabriz University of Medical Sciences, Tabriz, Iran
4 Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6 Department of Orthopedic Surgery, Shohada Educational Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence Address:
Hojjat Hossein Pourfeizi
Department of Orthopedic Surgery, Shohada Educational Hospital, Tabriz University of Medical Sciences, Tabriz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0300-1652.193861

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Background: Aminoglycosides and mainly gentamicin are the most important antimicrobial agents. Two different methods of administration exist: Single and multiple doses. There has always been a controversy about the less harmful administration method, to minimize adverse effects of gentamicin - deafness and renal insufficiency. In this study, it was aimed to compare two different methods of administration to figure out the least harmful treatment method. Materials and Methods: In a clinical study, eighty patients aged 12-55 years who were admitted with sepsis syndrome were included in the study; they were divided into two groups: The first group received single-dose treatment (5 mg/kg) whereas the second group was treated with multiple doses (1.7 mg/kg three times a day) of gentamicin. Results: The results show that blood urea nitrogen (BUN) and creatinine (CR) levels were decreased in the first group. Both blood urea nitrogen and creatinine and also mean glomerular filtration rate was increased in the same group. In the second group, mean BUN and CR levels were increased while the GFR was decreased in the same group. There was also a gradual increase in GFR in the first group. GFR <80 was decreased from 20% to 5.1% in the first group while increased from 5% to 27.5% in the second group. Results of audiometric studies show 6.1% hearing problem in the first group and 12.8% in the second one. Conclusions: Results of the present study showed that nephrotoxicity and ototoxicity are minimized in single-dose administration compared to multiples doses.


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